- Title
- Low blood-as levels and selected genotypes appears to be promising biomarkers for occurrence of colorectal cancer in women
- Creator
- Baszuk, Piotr; Stadnik, Paulina; Pietrzak, Sandra; Kładny, Józef; Scott, Rodney J.; Lubiński, Jan; Lener, Marcin R.; Marciniak, Wojciech; Derkacz, Róża; Jakubowska, Anna; Cybulski, Cezary; Huzarski, Tomasz; Gronwald, Jacek; Dębniak, Tadeusz; Białkowska, Katarzyna
- Relation
- Biomedicines Vol. 9, Issue 9, no. 1105
- Publisher Link
- http://dx.doi.org/10.3390/biomedicines9091105
- Publisher
- MDPI AG
- Resource Type
- journal article
- Date
- 2021
- Description
- In following study we examined whether blood arsenic (As) levels combined with specific polymorphisms in MT1B, GSTP1, ABCB1, NQO1, CRTC3, GPX1, SOD2, CAT, XRCC1, ERCC2 can be used as a marker for the detection of colorectal cancer (CRC) among Polish women. A retrospective case-control study of CRC included 83 CRC cases and 78 healthy controls. From each study participant pre-treatment peripheral blood was collected for As level measurement by inductively coupled– plasma mass spectrometry (ICP-MS). We estimated the odds ratio (OR) of the association between blood-As levels and CRC using multivariable unconditional logistic regression models. A low blood-As level (0.27–0.67 µg/L) was associated with an increased frequency of CRC (OR: 3.69; p = 0.005). This correlation was significantly greater when participants carried particular gene variants: CAT, rs1001179-nonCC (OR: 19.4; p = 0.001); ABCB1 rs2032582–CC (OR: 14.8; p = 0.024); GPX1 rs1050450-CC (OR: 11.6; p = 0.002) and CRTC3 rs12915189-nonGG (OR: 10.3; p = 0.003). Our study provides strong evidence that low blood-As levels are significantly associated with increased CRC occurrence and that particular gene variants significantly enhanced this correlation however, due to the novelty of these findings, we suggest further validation before a definitive statement that the combined effect of low blood-As levels with specific gene polymorphisms is a suitable CRC biomarker.
- Subject
- colorectal cancer; arsenic level; biomarkers; women; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1476295
- Identifier
- uon:49791
- Identifier
- ISSN:2227-9059
- Rights
- © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- Language
- eng
- Full Text
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